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Title: A highly efficient solid-phase synthesis of 1,3-substituted xanthines
Authors: He, R.
Lam, Y. 
Issue Date: Nov-2005
Citation: He, R., Lam, Y. (2005-11). A highly efficient solid-phase synthesis of 1,3-substituted xanthines. Journal of Combinatorial Chemistry 7 (6) : 916-920. ScholarBank@NUS Repository.
Abstract: A first solid-phase route to 1,3-substituted xanthines has been developed using PS-MB-CHO resin. Cyclocondensation of the polymer-bound aminoimidazole with isocyanates followed by alkylation provided 1,3-substituted xanthines in high yields. Libraries of 12 xanthines and 4 thioxanthines were prepared. © 2005 American Chemical Society.
Source Title: Journal of Combinatorial Chemistry
ISSN: 15204766
DOI: 10.1021/cc050088i
Appears in Collections:Staff Publications

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