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|Title:||Preparation of a chitin-apatite composite by in situ precipitation onto porous chitin scaffolds||Authors:||Wan, A.C.A.
In situ precipitation
|Issue Date:||15-Sep-1998||Citation:||Wan, A.C.A., Khor, E., Hastings, G.W. (1998-09-15). Preparation of a chitin-apatite composite by in situ precipitation onto porous chitin scaffolds. Journal of Biomedical Materials Research 41 (4) : 541-548. ScholarBank@NUS Repository. https://doi.org/10.1002/(SICI)1097-4636(19980915)41:4<541||Abstract:||Composites of chitin with calcium phosphate were obtained by in situ precipitation of the mineral from a supersaturated solution onto chitin scaffolds. The chitin scaffolds were obtained by freeze drying to give a highly porous structure possessing a polar surface favorable for apatite nucleation and growth. The extent and arrangement of calcium phosphate deposits on the chitin and substituted chitin scaffolds were explored. Up to 55% by mass of calcium phosphate could be incorporated into chitin scaffolds. Deposits on the chitin surface were of a continuous apatite carpet nature while deposits on carboxymethylated chitin surfaces displayed a spherical morphology. Carboxymethylation of chitin exerts an overall inhibitory effect towards calcium phosphate deposition, but it provides for site-specific nucleation of the mineral phase. In situ precipitation can be an important route in the future production of various polymer-calcium phosphate composites.||Source Title:||Journal of Biomedical Materials Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/75070||ISSN:||00219304||DOI:||10.1002/(SICI)1097-4636(19980915)41:4<541|
|Appears in Collections:||Staff Publications|
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