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Title: Image-guided Raman spectroscopy for in vivo diagnosis of gastric precancer at gastroscopy
Authors: Huang, Z. 
Bergholt, M.S. 
Zheng, W. 
Lin, K. 
Ho, K.Y.
Teh, M.
Yeoh, K.G.
Issue Date: 2010
Citation: Huang, Z.,Bergholt, M.S.,Zheng, W.,Lin, K.,Ho, K.Y.,Teh, M.,Yeoh, K.G. (2010). Image-guided Raman spectroscopy for in vivo diagnosis of gastric precancer at gastroscopy. AIP Conference Proceedings 1267 : 438-440. ScholarBank@NUS Repository.
Abstract: We report on the implementation of a narrow-band image (NBI)-guided Raman endoscopy for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric tissue within 0.5 second at gastroscopy. Significant Raman spectral differences are observed between normal and dysplastic gastric tissue. PCA-LDA modeling on in vivo Raman spectra yields a diagnostic sensitivity of 94.4% and specificity of 96.3% for distinction of gastric dysplastic tissue. This study suggests that NBI-guided Raman endoscopy associated with PCA-LDA algorithms has potential for noninvasive, in vivo diagnosis and detection of gastric precancer during clinical gastroscopic examination. © 2010 American Institute of Physics.
Source Title: AIP Conference Proceedings
ISBN: 9780735408180
ISSN: 0094243X
DOI: 10.1063/1.3482603
Appears in Collections:Staff Publications

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