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Title: Impulse parametric sensitivity analysis
Authors: Perumal, T.M.
Gunawan, R. 
Keywords: Model
Sensitivity Analysis
Systems Biology
Issue Date: 2011
Citation: Perumal, T.M.,Gunawan, R. (2011). Impulse parametric sensitivity analysis. IFAC Proceedings Volumes (IFAC-PapersOnline) 18 (PART 1) : 9686-9690. ScholarBank@NUS Repository.
Abstract: Complexity often limits human intuition in understanding system behavior, motivating the creation and analysis of mathematical models to understand these systems. One of the most commonly used analyses is the classical parametric sensitivity analysis (PSA), which maps out the parametric dependence of system behavior. In this article, we present a novel sensitivity analysis, called impulseparametric sensitivity analyses (iPSA), which is based on impulse perturbations to model parameters. Hence, the iPSA gives a step-by-step mechanistic insight on how a particular output behavior is accomplished and complementarily how (an impulse) perturbation propagates through the network. More specifically iPSA coefficients can reveal which parameters are essential and when they become important. The efficacy of this analysis is demonstrated on examples drawn from biology: the Fas-induced cell death model of human Jurkat T-cells. © 2011 IFAC.
Source Title: IFAC Proceedings Volumes (IFAC-PapersOnline)
ISBN: 9783902661937
ISSN: 14746670
DOI: 10.3182/20110828-6-IT-1002.03771
Appears in Collections:Staff Publications

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