Please use this identifier to cite or link to this item:
|Title:||Vitamin E TPGS as a molecular biomaterial for drug delivery||Authors:||Zhang, Z.
|Issue Date:||Jun-2012||Citation:||Zhang, Z., Tan, S., Feng, S.-S. (2012-06). Vitamin E TPGS as a molecular biomaterial for drug delivery. Biomaterials 33 (19) : 4889-4906. ScholarBank@NUS Repository.||Abstract:||d-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) is a water-soluble derivative of natural Vitamin E, which is formed by esterification of Vitamin E succinate with polyethylene glycol (PEG). As such, it has advantages of PEG and Vitamin E in application of various nanocarriers for drug delivery, including extending the half-life of the drug in plasma and enhancing the cellular uptake of the drug. TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a hydrophile/lipophile balance (HLB) value of 13.2 and a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles, which would be able to realize sustained, controlled and targeted drug delivery as well as to overcome multidrug resistance (MDR) and to promote oral drug delivery as an inhibitor of P-glycoprotein (P-gp). In this review, we briefly discuss its physicochemical and pharmaceutical properties and its wide applications in composition of the various nanocarriers for drug delivery, which we call TPGS-based drug delivery systems. © 2012 Elsevier Ltd.||Source Title:||Biomaterials||URI:||http://scholarbank.nus.edu.sg/handle/10635/68459||ISSN:||01429612|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 6, 2018
WEB OF SCIENCETM
checked on Dec 31, 2018
checked on May 17, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.