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Title: Supramolecular polymers based on cyclodextrins for drug and gene delivery
Authors: Li, J.J.
Zhao, F.
Li, J. 
Keywords: Cyclodextrin
Drug delivery
Gene delivery
Supramolecular structure
Issue Date: 2011
Citation: Li, J.J., Zhao, F., Li, J. (2011). Supramolecular polymers based on cyclodextrins for drug and gene delivery. Advances in Biochemical Engineering/Biotechnology 125 : 207-249. ScholarBank@NUS Repository.
Abstract: Supramolecular polymers based on cyclodextrins (CDs) have inspired interesting and rapid developments as novel biomaterials in a broad range of drug and gene delivery applications, due to their low cytotoxicity, controllable size, and unique architecture. This review will summarize the potential applications of polyrotaxanes in the field of drug delivery and gene delivery. Generally, cyclodextrin- based biodegradable polypseudorotaxane hydrogels could be used as a promising injectable drug delivery system for sustained and controlled drug release. Temperature-responsive, pH-sensitive, and controllable hydrolyzable polyrotaxane hydrogels have attracted much attention because of their controllable properties, and the self-assembly micelles formed by amphiphilic copolymer threaded with CDs could be used as a carrier for controlled and sustained drug release. Polyrotaxanes with drug or ligand conjugated CDs threaded on a polymer chain with a biodegradable end group could be useful for controlled and multivalent targeted delivery. In the field of gene delivery, cationic polyrotaxanes consisting of multiple OEI-grafted CDs threaded on a block copolymer chain are attractive non-viral gene carries due to the strong DNA-binding ability, low cytotoxicity, and high gene delivery capability. Furthermore, cytocleavable end-caps were introduced in the polyrotaxane systems in order to ensure efficient endosomal escape for intracellular trafficking of DNA. The development of the supramolecular approach using CD-containing polyrotaxanes is expected to provide a new paradigm for biomaterials. © Springer-Verlag Berlin Heidelberg 2010.
Source Title: Advances in Biochemical Engineering/Biotechnology
ISBN: 9783642219481
ISSN: 07246145
DOI: 10.1007/10_2010_91
Appears in Collections:Staff Publications

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