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Title: Interface tissue engineering: Next phase in musculoskeletal tissue repair
Authors: Sahoo, S. 
Teh, T.K. 
He, P.
Toh, S.L. 
Goh, J.C. 
Keywords: Functional tissue engineering
Orthopaedic interfaces
Regenerative medicine
Issue Date: May-2011
Citation: Sahoo, S.,Teh, T.K.,He, P.,Toh, S.L.,Goh, J.C. (2011-05). Interface tissue engineering: Next phase in musculoskeletal tissue repair. Annals of the Academy of Medicine Singapore 40 (5) : 246-251. ScholarBank@NUS Repository.
Abstract: Increasing incidence of musculoskeletal injuries coupled with limitations in the current treatment options have necessitated tissue engineering and regenerative medicine- based approaches. Moving forward from engineering isolated musculoskeletal tissues, research strategies are now being increasingly focused on repairing and regenerating the interfaces between dissimilar musculoskeletal tissues with the aim to achieve seamless integration of engineered musculoskeletal tissues. This article reviews the state-of-the-art in the tissue engineering of musculoskeletal tissue interfaces with a focus on Singapore's contribution in this emerging field. Various biomimetic scaffold and cellbased strategies, the use of growth factors, gene therapy and mechanical loading, as well as animal models for functional validation of the tissue engineering strategies are discussed.
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

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