Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biotechadv.2011.07.001
DC FieldValue
dc.titleImmunoglobulin-M purification - challenges and perspectives
dc.contributor.authorGautam, S.
dc.contributor.authorLoh, K.-C.
dc.date.accessioned2014-06-18T06:11:34Z
dc.date.available2014-06-18T06:11:34Z
dc.date.issued2011-11
dc.identifier.citationGautam, S., Loh, K.-C. (2011-11). Immunoglobulin-M purification - challenges and perspectives. Biotechnology Advances 29 (6) : 840-849. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biotechadv.2011.07.001
dc.identifier.issn07349750
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/68272
dc.description.abstractExtensive research in the past two decades has led to the realization of Immunoglobulin-M (IgM) as a potential therapeutic and diagnostic agent. In order to fully exploit the potential of IgM, large quantities, in a highly pure and active form, must be available at low cost for performing clinical trials, characterization studies and quantitative-structure activity analyses. The complex physico-chemical properties, in particular its large size and labile nature renders downstream purification of IgM difficult. This review discusses the limitations and challenges associated with the current IgM purification strategies and proposes future directions for research. The uniqueness of affinity chromatography, specifically biomimetic affinity chromatography for protein purification is highlighted and its potential for IgM purification is discussed. © 2011 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biotechadv.2011.07.001
dc.sourceScopus
dc.subjectAffinity chromatography
dc.subjectBiomimetic ligands
dc.subjectImmunoglobulin-M
dc.subjectPurification
dc.typeReview
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.biotechadv.2011.07.001
dc.description.sourcetitleBiotechnology Advances
dc.description.volume29
dc.description.issue6
dc.description.page840-849
dc.description.codenBIADD
dc.identifier.isiut000296821900025
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.