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Title: Solubility phase diagram of praziquantel enantiomeric system
Authors: Lim, B.-G. 
Tan, R.B.H. 
Ng, S.-C. 
Ching, C.-B. 
Keywords: crystallisation
optical resolution
solid solution
Issue Date: 1995
Citation: Lim, B.-G.,Tan, R.B.H.,Ng, S.-C.,Ching, C.-B. (1995). Solubility phase diagram of praziquantel enantiomeric system. Chirality 7 (2) : 74-81. ScholarBank@NUS Repository.
Abstract: The solubility behaviour of praziquantel enantiomeric system at -15°C, 4°C, and 15°C is presented. This system exhibits both a pseudoracemate behaviour and one which leads to the formation of enantiomerically pure crystals. For solutions with lower enantiomeric purity, the pseudoracemate behaviour is more prominent. Solid solutions are formed when the mixtures of the enantiomers are crystallised. The phase diagram shows a complete absence of a eutectic. For mixtures with higher enantiomeric purity, pure crystals of the excess enantiomer are obtained when the solution is crystallised. Temperature dependency of this polymorphism is not significant. With these phase diagrams, a method is suggested to obtain enantiomerically pure isomers of praziquantel from a partially resolved mixture.
Source Title: Chirality
ISSN: 08990042
Appears in Collections:Staff Publications

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