Please use this identifier to cite or link to this item:
Title: The use of molecular fluorescent markers to monitor absorption and distribution of xenobiotics in a silkworm model
Authors: Tansil, N.C.
Li, Y. 
Koh, L.D.
Peng, T.C.
Win, K.Y.
Liu, X.Y. 
Han, M.-Y. 
Keywords: ADME
Tissue engineering
Issue Date: Dec-2011
Citation: Tansil, N.C., Li, Y., Koh, L.D., Peng, T.C., Win, K.Y., Liu, X.Y., Han, M.-Y. (2011-12). The use of molecular fluorescent markers to monitor absorption and distribution of xenobiotics in a silkworm model. Biomaterials 32 (36) : 9576-9583. ScholarBank@NUS Repository.
Abstract: The fate of xenobiotics in living organisms is determined by their in vivo absorption, distribution, metabolism and excretion. A convenient and scalable animal model of these biological processes is thus highly beneficial in understanding the effects of xenobiotics. Here we present a silkworm model to investigate the molecular properties-directed absorption, distribution and excretion of fluorescent compounds as model xenobiotics through introducing the compounds into the silkworm's diet and monitoring the resulting color and fluorescence in the silkworm's body. The efficient uptake of xenobiotics into silk has been further studied through quantitative analysis of the intrinsically colored and highly luminescent silk secreted by silkworm. Our findings provide first-hand insights to better understand the molecular properties that allow specific materials to be incorporated into silk while it is being produced in the silk gland. The use of resulting luminescent silk as scaffold for tissue engineering application has been demonstrated to clearly reveal the interaction of silk with cells. Furthermore, this new development also paves a way to produce various functional silk embedded with stimuli-sensitive dyes or drugs as novel biomaterials for in vivo applications. © 2011 Elsevier Ltd.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2011.08.081
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jun 23, 2022


checked on Jun 23, 2022

Page view(s)

checked on Jun 23, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.