Please use this identifier to cite or link to this item:
Title: Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo.
Authors: Lam, C.X. 
Hutmacher, D.W.
Schantz, J.T.
Woodruff, M.A.
Teoh, S.H.
Issue Date: 1-Sep-2009
Citation: Lam, C.X.,Hutmacher, D.W.,Schantz, J.T.,Woodruff, M.A.,Teoh, S.H. (2009-09-01). Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo.. Journal of biomedical materials research. Part A 90 (3) : 906-919. ScholarBank@NUS Repository.
Abstract: The use of polycaprolactone (PCL) as a biomaterial, especially in the fields of drug delivery and tissue engineering, has enjoyed significant growth. Understanding how such a device or scaffold eventually degrades in vivo is paramount as the defect site regenerates and remodels. Degradation studies of three-dimensional PCL and PCL-based composite scaffolds were conducted in vitro (in phosphate buffered saline) and in vivo (rabbit model). Results up to 6 months are reported. All samples recorded virtually no molecular weight changes after 6 months, with a maximum mass loss of only about 7% from the PCL-composite scaffolds degraded in vivo, and a minimum of 1% from PCL scaffolds. Overall, crystallinity increased slightly because of the effects of polymer recrystallization. This was also a contributory factor for the observed stiffness increment in some of the samples, while only the PCL-composite scaffold registered a decrease. Histological examination of the in vivo samples revealed good biocompatibility, with no adverse host tissue reactions up to 6 months. Preliminary results of medical-grade PCL scaffolds, which were implanted for 2 years in a critical-sized rabbit calvarial defect site, are also reported here and support our scaffold design goal for gradual and late molecular weight decreases combined with excellent long-term biocompatibility and bone regeneration.
Source Title: Journal of biomedical materials research. Part A
ISSN: 15524965
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Mar 29, 2021

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.