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Title: Early diagnosis of oral cancer based on the surface plasmon resonance of gold nanoparticles
Authors: Kah, J.C.Y. 
Kho, K.W.
Lee, C.G.L.
Sheppard, C.J.R. 
Shen, Z.X.
Soo, K.C.
Olivo, M.C.
Keywords: Confocal microscopy
Coupled surface plasmon resonance
Epidermal growth factor receptor
Epithelial carcinoma
Gold nanoparticles
Oral cancer
Reflectance imaging
Surface enhanced raman scattering
Issue Date: 2007
Citation: Kah, J.C.Y.,Kho, K.W.,Lee, C.G.L.,Sheppard, C.J.R.,Shen, Z.X.,Soo, K.C.,Olivo, M.C. (2007). Early diagnosis of oral cancer based on the surface plasmon resonance of gold nanoparticles. International Journal of Nanomedicine 2 (4) : 785-798. ScholarBank@NUS Repository.
Abstract: The high mortality rate in cancer such as oral squamous cell carcinoma is commonly attributed to the difficulties in detecting the disease at an early treatable stage. In this study, we exploited the ability of gold nanoparticles to undergo coupled surface plasmon resonance and set up strong electric fields when closely-spaced to improve the molecular contrast signal in reflectance-based imaging and also to enhance the Raman signal of bioanalytes in cancer. Colloidal gold nanoparticles were synthesized and conjugated to anti-epidermal growth factor receptor (EGFR) for imaging. A self-assembled surface enhanced Raman scattering (SERS)-active gold nanoparticle monolayer film was also developed as a biosensing surface using a simple drop-dry approach. We have shown that gold nanoparticles could elicit an optical contrast to discriminate between cancerous and normal cells and their conjugation with antibodies allowed them to map the expression of relevant biomarkers for molecular imaging under confocal reflectance microscopy. We have also shown that the SERS spectra of saliva from the closely-packed gold nanoparticles films was differentiable between those acquired from normal individuals and oral cancer patients, thus showing promise of a simple SERS-based saliva assay for early diagnosis of oral cancer. © 2007 Dove Medical Press Limited. All rights reserved.
Source Title: International Journal of Nanomedicine
ISSN: 11769114
Appears in Collections:Staff Publications

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