Please use this identifier to cite or link to this item: https://doi.org/10.1364/OL.38.002321
Title: Development of a beveled fiber-optic confocal Rama probe for enhancing in vivo epithelia tissue Raman measurements at endoscopy
Authors: Wang, J.
Bergholt, M.S. 
Zheng, W. 
Huang, Z. 
Issue Date: 1-Jul-2013
Citation: Wang, J., Bergholt, M.S., Zheng, W., Huang, Z. (2013-07-01). Development of a beveled fiber-optic confocal Rama probe for enhancing in vivo epithelia tissue Raman measurements at endoscopy. Optics Letters 38 (13) : 2321-2323. ScholarBank@NUS Repository. https://doi.org/10.1364/OL.38.002321
Abstract: We reporton the developmentofabeveled fiber-optic confocal Raman probe coupled with a ball lens for enhancing in vivo epithelial tissue Raman measurements at endoscopy. Our Monte Carlo simulations show that by selecting a proper fiber-ball lens distance and beveled angle of collection fibers, the confocal Raman probe design can be optimized for maximizing shallower tissue Raman measurements in epithelial tissue; in addition, the ratio of epithelium to stromal Raman photons collected using an optimized confocal Raman probe is approximately 19-fold higher than that usingavolume-type Raman probe. Further experiments confirm that the confocal Raman endoscopic probe developed is in favor of probing superficial tissue Raman signals from a two-layer tissue phantom as well as esophagus tissue in vivo during endoscopy. This work suggests the great potential of applying the beveled fiber-optic confocal Raman probe for improving in vivo diagnosis of precancer occurring in epithelial tissue at endoscopy. © 2013 Optical Society of America.
Source Title: Optics Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/67001
ISSN: 01469592
DOI: 10.1364/OL.38.002321
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