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Title: Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia
Authors: Qiu, A. 
Younes, L.
Wang, L.
Ratnanather, J.T.
Gillepsie, S.K.
Kaplan, G.
Csernansky, J.
Miller, M.I.
Keywords: Cingulate gyrus
Cortical thickness
Gaussian random field
Large deformation diffeomorphic metric mapping (LDDMM)
The Laplace-Beltrami operator
Issue Date: 1-Sep-2007
Citation: Qiu, A., Younes, L., Wang, L., Ratnanather, J.T., Gillepsie, S.K., Kaplan, G., Csernansky, J., Miller, M.I. (2007-09-01). Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia. NeuroImage 37 (3) : 821-833. ScholarBank@NUS Repository.
Abstract: Spatial normalization is a crucial step in assessing patterns of neuroanatomical structure and function associated with health and disease. Errors that occur during spatial normalization can influence hypothesis testing due to the dimensionalities of mapping algorithms and anatomical manifolds (landmarks, curves, surfaces, volumes) used to drive the mapping algorithms. The primary aim of this paper is to improve statistical inference using multiple anatomical manifolds and large deformation diffeomorphic metric mapping (LDDMM) algorithms. We propose that combining information generated by the various manifolds and algorithms improves the reliability of hypothesis testing. We used this unified approach to assess variation in the thickness of the cingulate gyrus in subjects with schizophrenia and healthy comparison subjects. Three different LDDMM algorithms for mapping landmarks, curves and triangulated meshes were used to transform thickness maps of the cingulate surfaces into an atlas coordinate system. We then tested for group differences by combining the information from the three types of anatomical manifolds and LDDMM mapping algorithms. The unified approach provided reliable statistical results and eliminated ambiguous results due to surface mismatches. Subjects with schizophrenia had non-uniform cortical thinning over the left and right cingulate gyri, especially in the anterior portion, as compared to healthy comparison subjects. © 2007 Elsevier Inc. All rights reserved.
Source Title: NeuroImage
ISSN: 10538119
DOI: 10.1016/j.neuroimage.2007.05.007
Appears in Collections:Staff Publications

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