Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201100191
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dc.titleChitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery
dc.contributor.authorBao, H.
dc.contributor.authorPan, Y.
dc.contributor.authorPing, Y.
dc.contributor.authorSahoo, N.G.
dc.contributor.authorWu, T.
dc.contributor.authorLi, L.
dc.contributor.authorLi, J.
dc.contributor.authorGan, L.H.
dc.date.accessioned2014-06-17T09:42:47Z
dc.date.available2014-06-17T09:42:47Z
dc.date.issued2011-06-06
dc.identifier.citationBao, H., Pan, Y., Ping, Y., Sahoo, N.G., Wu, T., Li, L., Li, J., Gan, L.H. (2011-06-06). Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small 7 (11) : 1569-1578. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201100191
dc.identifier.issn16136810
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/66963
dc.description.abstractThe covalent functionalization of graphene oxide (GO) with chitosan (CS) is successfully accomplished via a facile amidation process. The CS-grafted GO (GO-CS) sheets consist of about 64 wt.% CS, which imparts them with a good aqueous solubility and biocompatibility. Additionally, the physicochemical properties of GO-CS are studied. As a novel nanocarrier, GO-CS is applied to load a water-insoluble anticancer drug, camptothecin (CPT), via π-π stacking and hydrophobic interactions. It is demonstrated that GO-CS possesses a superior loading capacity for CPT, and the GO-CS-CPT complexes show remarkably high cytotoxicity in HepG2 and HeLa cell lines compared to the pure drug. At the same time, GO-CS is also able to condense plasmid DNA into stable, nanosized complexes, and the resulting GO-CS/pDNA nanoparticles exhibit reasonable transfection efficiency in HeLa cells at certain nitrogen/phosphate ratios. Therefore, the GO-CS nanocarrier is able to load and deliver both anticancer drugs and genes. The covalent functionalization of graphene oxide (GO) with chitosan (CS) is accomplished via a facile method. It is demonstrated that GO-CS possesses a superior loading capacity for camptothecin (CPT), and the GO-CS-CPT complexes show remarkably high cytotoxicity in cancer cells. In addition, GO-CS is able to transport plasmid DNA into HeLa cells with a reasonable transfection efficiency. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/smll.201100191
dc.sourceScopus
dc.subjectchitosan
dc.subjectdrug delivery
dc.subjectgene delivery
dc.subjectgraphene oxide
dc.subjectnanocarriers
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1002/smll.201100191
dc.description.sourcetitleSmall
dc.description.volume7
dc.description.issue11
dc.description.page1569-1578
dc.identifier.isiut000291107700011
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