Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.31976
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dc.titleCationic supramolecules consisting of oligoethylenimine-grafted α-cyclodextrins threaded on poly(ethylene oxide) for gene delivery
dc.contributor.authorYang, C.
dc.contributor.authorLi, H.
dc.contributor.authorWang, X.
dc.contributor.authorLi, J.
dc.date.accessioned2014-06-17T09:42:40Z
dc.date.available2014-06-17T09:42:40Z
dc.date.issued2009-04
dc.identifier.citationYang, C., Li, H., Wang, X., Li, J. (2009-04). Cationic supramolecules consisting of oligoethylenimine-grafted α-cyclodextrins threaded on poly(ethylene oxide) for gene delivery. Journal of Biomedical Materials Research - Part A 89 (1) : 13-23. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.31976
dc.identifier.issn15493296
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/66954
dc.description.abstractIn this study, three cationic polyrotaxanes composed of multiple oligoethylenimine-grafted α-cyclo-dextrin rings threaded on a poly(ethylene oxide) chain have been synthesized and characterized, and investigated for gene delivery. All three cationic polyrotaxanes could efficiently compact pDNA into small nanoparticles, with diameters ranging from 100 to 200 nm. In both BHK-21 and MES-SA cell lines, the transfection efficiency mediated by the cationic polyrotaxanes were comparable or even higher than that of branched polyethylenimine (PEI) with a molecular weight of 25 kDa, which is one of the most efficient gene-delivery vectors to date. Moreover, the cationic polyrotaxanes showed much lower cytotoxicity than branched PEI (25 kDa). Hence, these cationic poly rotaxanes have high potentials as new carriers for gene delivery. © 2008 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jbm.a.31976
dc.sourceScopus
dc.subjectCationic polymer
dc.subjectCyclodextrin
dc.subjectGene delivery
dc.subjectPolyethylenimine
dc.subjectSupramolecule
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1002/jbm.a.31976
dc.description.sourcetitleJournal of Biomedical Materials Research - Part A
dc.description.volume89
dc.description.issue1
dc.description.page13-23
dc.description.codenJBMRC
dc.identifier.isiut000263981300002
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