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Title: An electrospun polycaprolactone-collagen membrane for the resurfacing of cartilage defects
Authors: Ho, S.T.B.
Ekaputra, A.K. 
Hui, J.H.
Hutmacher, D.W.
Keywords: Collagen and periosteal substitute
Electrospun mesh
Issue Date: Jun-2010
Citation: Ho, S.T.B., Ekaputra, A.K., Hui, J.H., Hutmacher, D.W. (2010-06). An electrospun polycaprolactone-collagen membrane for the resurfacing of cartilage defects. Polymer International 59 (6) : 808-817. ScholarBank@NUS Repository.
Abstract: A polycaprolactone (PCL)-collagen electrospun mesh is proposed as a novel alternative to the conventional periosteal graft in autologous chondrocyte implantation. This is the first known attempt in designing a cartilage resurfacing membrane using a mechanically resilient PCL mesh with a weight-average molecular weight of 139 300 that is enhanced with bioactive collagen. PCL-collagen 10, 20 and 40% electrospun meshes (Coll-10, Coll-20 and Coll-40) were evaluated and it was discovered that the retention of surface collagen could only be achieved in Coll-20 and Coll-40. Furthermore Coll-20 was stiffer and stronger than Coll-40 and it satisfied the mechanical demands at the cartilage implant site. When seeded with mesenchymal stem cells (MSCs), the cells adhered on the surface of the Coll-20 mesh and they remained viable over a period of 28 days; however, they were unable to infiltrate through the dense meshwork. Cell compatibility was also noted in the chondrogenic environment as the MSCs differentiated into chondrocytes with the expression of Sox9, aggrecan and collagen II. More importantly, the mesh did not induce a hypertrophic response from the cells. The current findings support the use of Coll-20 as a cartilage patch, and future implantation studies are anticipated. © 2010 Society of Chemical Industry.
Source Title: Polymer International
ISSN: 09598103
DOI: 10.1002/pi.2792
Appears in Collections:Staff Publications

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