Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/66728
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dc.titleOptimization of the reversed-phase high-performance, liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column
dc.contributor.authorVelmurugan, T.
dc.contributor.authorChing, C.B.
dc.contributor.authorNg, S.C.
dc.contributor.authorBai, Z.W.
dc.contributor.authorOng, T.T.
dc.date.accessioned2014-06-17T08:33:45Z
dc.date.available2014-06-17T08:33:45Z
dc.date.issued2002
dc.identifier.citationVelmurugan, T.,Ching, C.B.,Ng, S.C.,Bai, Z.W.,Ong, T.T. (2002). Optimization of the reversed-phase high-performance, liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column. Chromatographia 56 (3-4) : 229-232. ScholarBank@NUS Repository.
dc.identifier.issn00095893
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/66728
dc.description.abstractHeptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin has been synthesized and chemically immobilized on silica gel for use as a chiral stationary phase (PC-CSP) for analytical separation of the enantiomers of chiral drugs. Separation of the enantiomers of tolperisone was studied by high-performance liquid chromatography under reversed-phase conditions. The chromatographic conditions were optimized by varying mobile phase pH, composition, ionic strength, and velocity; 40:60 methanol-1% triethylammonium acetate (TEAA) buffer, pH 5.5, was found to be the most suitable for this separation.
dc.sourceScopus
dc.subjectβ-Cyclodextrin
dc.subjectColumn liquid chromatography
dc.subjectEnantiomer separation
dc.subjectOptimizatio
dc.subjectTolperisone
dc.typeArticle
dc.contributor.departmentCHEMICAL AND PROCESS ENGINEERING CENTRE
dc.contributor.departmentCHEMISTRY
dc.contributor.departmentCHEMICAL & ENVIRONMENTAL ENGINEERING
dc.description.sourcetitleChromatographia
dc.description.volume56
dc.description.issue3-4
dc.description.page229-232
dc.description.codenCHRGB
dc.identifier.isiutNOT_IN_WOS
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