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https://scholarbank.nus.edu.sg/handle/10635/64970
Title: | PEOlated micelle/silica as dual-layer protection of quantum dots for stable and targeted bioimaging | Authors: | Zhang, Y. Wang, M. Zheng, Y.-G. Tan, H. Hsu, B.Y.-W. Yang, Z.-C. Wong, S.Y. Chang, A.Y.-C. Choolani, M. Li, X. Wang, J. |
Keywords: | core/shell micelle quantum dots silica targeted bioimaging |
Issue Date: | 13-Aug-2013 | Citation: | Zhang, Y., Wang, M., Zheng, Y.-G., Tan, H., Hsu, B.Y.-W., Yang, Z.-C., Wong, S.Y., Chang, A.Y.-C., Choolani, M., Li, X., Wang, J. (2013-08-13). PEOlated micelle/silica as dual-layer protection of quantum dots for stable and targeted bioimaging. Chemistry of Materials 25 (15) : 2976-2985. ScholarBank@NUS Repository. | Abstract: | CdSe/CdS/ZnS quantum dots (QDs) have been successfully encapsulated into poly(ethylene oxide) (PEO)-based polymeric micelle/silica dual layers via interfacial templating condensation. The encapsulation follows a green and straightforward microemulsion mechanism that directly proceeds in a near-neutral pH aqueous environment. No detriment to the optical properties of QDs is observed during encapsulation. The core-shell nanoparticles generated possess a polymeric micelle framework with a single QD encapsulated in the hydrophobic micellar core, an ultrathin (<5 nm in thickness) yet robust silica shell confined to the micellar core/corona interface and free PEO chains dangling on the surface. The free PEO chains effectively prevent nonspecific adsorption of biomolecules to the nanoparticles. Double shielding of polymeric micelle/silica shell remarkably improves the fluorescence resistance of QDs to strong acids and highly salted buffers. In vitro testing using MDA-MB-231 breast cancer cells demonstrates that these organic/inorganic dual layer-protected QDs conjugated with folate show noncytotoxicity and bright fluorescence cellular imaging with high target specificity. © 2013 American Chemical Society. | Source Title: | Chemistry of Materials | URI: | http://scholarbank.nus.edu.sg/handle/10635/64970 | ISSN: | 08974756 |
Appears in Collections: | Staff Publications |
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