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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jmmm.2006.11.201
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dc.titleGene delivery to the heart by magnetic nanobeads
dc.contributor.authorLi, W.
dc.contributor.authorNesselmann, C.
dc.contributor.authorZhou, Z.
dc.contributor.authorOng, L.-L.
dc.contributor.authorÖri, F.
dc.contributor.authorTang, G.
dc.contributor.authorKaminski, A.
dc.contributor.authorLützow, K.
dc.contributor.authorLendlein, A.
dc.contributor.authorLiebold, A.
dc.contributor.authorStamm, C.
dc.contributor.authorWang, J.
dc.contributor.authorSteinhoff, G.
dc.contributor.authorMa, N.
dc.date.accessioned2014-06-17T07:58:43Z
dc.date.available2014-06-17T07:58:43Z
dc.date.issued2007-04
dc.identifier.citationLi, W., Nesselmann, C., Zhou, Z., Ong, L.-L., Öri, F., Tang, G., Kaminski, A., Lützow, K., Lendlein, A., Liebold, A., Stamm, C., Wang, J., Steinhoff, G., Ma, N. (2007-04). Gene delivery to the heart by magnetic nanobeads. Journal of Magnetism and Magnetic Materials 311 (1 SPEC. ISS.) : 336-341. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jmmm.2006.11.201
dc.identifier.issn03048853
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/64893
dc.description.abstractGene delivery with non-viral gene vectors to the cardiovascular system suffers from low transfection efficiency. In this study, magnetic fields were investigated to assist cardiovascular gene delivery via magnetic nanobeads both in vitro and in vivo. The magnetic field was provided with a 1120 mT Nd-Fe-B permanent magnet while complexes of poly-ethyleneimine (PEI) and various DNA plasmids were conjugated with magnetic nanobeads (MNB) using a Sulfo-NHS-LC-Biotin linker. In vitro results showed that transfection in two cell lines was 30-80-fold higher in magnetically conjugated MNB/PEI/DNA complexes than transfection from PEI/DNA complexes alone. Similarly, in vivo results using mouse models showed 72 h after injection observable gene expression in the heart with conjugated MNB/PEI/DNA complexes, but barely with PEI/DNA complexes alone. © 2006 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jmmm.2006.11.201
dc.sourceScopus
dc.subjectCardiovascular system
dc.subjectConjugation
dc.subjectGene targeting
dc.subjectMagnetic
dc.subjectPoly-ethyleneimine (PEI)
dc.typeArticle
dc.contributor.departmentMATERIALS SCIENCE AND ENGINEERING
dc.description.doi10.1016/j.jmmm.2006.11.201
dc.description.sourcetitleJournal of Magnetism and Magnetic Materials
dc.description.volume311
dc.description.issue1 SPEC. ISS.
dc.description.page336-341
dc.description.codenJMMMD
dc.identifier.isiut000245524800068
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