Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.b.30503
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dc.titleBiodegradable polymer-silica xerogel composite microspheres for controlled release of gentamicin
dc.contributor.authorXue, J.M.
dc.contributor.authorTan, C.H.
dc.contributor.authorLukito, D.
dc.date.accessioned2014-06-17T07:57:51Z
dc.date.available2014-06-17T07:57:51Z
dc.date.issued2006-08
dc.identifier.citationXue, J.M., Tan, C.H., Lukito, D. (2006-08). Biodegradable polymer-silica xerogel composite microspheres for controlled release of gentamicin. Journal of Biomedical Materials Research - Part B Applied Biomaterials 78 (2) : 417-422. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.b.30503
dc.identifier.issn00219304
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/64817
dc.description.abstractSingle and double layered composite microspheres were prepared by encapsulating gentamicin-loaded silica xerogels with biodegradable PLGA polymers (poly(DL-lactide-co-glycolide)). The in vitro drug release properties of both the composite microspheres were investigated. The single layered composite microspheres showed a high initial burst, followed by two sustained release stages lasting for ∼6 weeks. The two sustained release stages of the single layered composite microspheres could be attributed to the swelling and bulk erosion of the polymer encapsulations, respectively. In comparison with the single layered composite microspheres, the double layered composite microspheres realized a much reduced initial burst together with three sustained release stages. The whole release period of the double layered composite microspheres could last more than 9 weeks. These distinct behaviors make the double layered composite microspheres promising as a new drug release material for localized drug delivery applications. © 2006 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jbm.b.30503
dc.sourceScopus
dc.subjectComposite microspheres
dc.subjectDrug release
dc.subjectGentamicin
dc.subjectPLGA polymer
dc.subjectSilica xerogel
dc.typeArticle
dc.contributor.departmentMATERIALS SCIENCE
dc.contributor.departmentMATERIALS SCIENCE AND ENGINEERING
dc.description.doi10.1002/jbm.b.30503
dc.description.sourcetitleJournal of Biomedical Materials Research - Part B Applied Biomaterials
dc.description.volume78
dc.description.issue2
dc.description.page417-422
dc.description.codenJBMRG
dc.identifier.isiut000239300000028
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