Please use this identifier to cite or link to this item:
|Title:||Biodegradable polymer-silica xerogel composite microspheres for controlled release of gentamicin||Authors:||Xue, J.M.
|Issue Date:||Aug-2006||Citation:||Xue, J.M., Tan, C.H., Lukito, D. (2006-08). Biodegradable polymer-silica xerogel composite microspheres for controlled release of gentamicin. Journal of Biomedical Materials Research - Part B Applied Biomaterials 78 (2) : 417-422. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.b.30503||Abstract:||Single and double layered composite microspheres were prepared by encapsulating gentamicin-loaded silica xerogels with biodegradable PLGA polymers (poly(DL-lactide-co-glycolide)). The in vitro drug release properties of both the composite microspheres were investigated. The single layered composite microspheres showed a high initial burst, followed by two sustained release stages lasting for ∼6 weeks. The two sustained release stages of the single layered composite microspheres could be attributed to the swelling and bulk erosion of the polymer encapsulations, respectively. In comparison with the single layered composite microspheres, the double layered composite microspheres realized a much reduced initial burst together with three sustained release stages. The whole release period of the double layered composite microspheres could last more than 9 weeks. These distinct behaviors make the double layered composite microspheres promising as a new drug release material for localized drug delivery applications. © 2006 Wiley Periodicals, Inc.||Source Title:||Journal of Biomedical Materials Research - Part B Applied Biomaterials||URI:||http://scholarbank.nus.edu.sg/handle/10635/64817||ISSN:||00219304||DOI:||10.1002/jbm.b.30503|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 22, 2020
WEB OF SCIENCETM
checked on Oct 14, 2020
checked on Oct 24, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.