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|Title:||The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes||Authors:||Liu, L.
|Issue Date:||7-May-2013||Citation:||Liu, L., Yang, J., Xie, J., Luo, Z., Jiang, J., Yang, Y.Y., Liu, S. (2013-05-07). The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes. Nanoscale 5 (9) : 3834-3840. ScholarBank@NUS Repository.||Abstract:||Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potent nano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge. Here, we report the cell penetrating peptide catalyzed formation of antimicrobial silver nanoparticles in N,N-dimethylformamide. The novel nano-composite demonstrated a distinctly enhanced biocidal effect toward bacteria (Gram-positive Bacillus subtilis, Gram-negative Escherichia coli) and pathogenic yeast (Candida albicans), as compared to triangular and extremely small silver nanoparticles. In addition, a satisfactory biocompatibility was verified by a haemolysis test. Our results provide a paradigm in developing strategies that can maximize the silver nanoparticle application potentials while minimizing the toxic effects. © 2013 The Royal Society of Chemistry.||Source Title:||Nanoscale||URI:||http://scholarbank.nus.edu.sg/handle/10635/64716||ISSN:||20403364|
|Appears in Collections:||Staff Publications|
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