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|Title:||Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging||Authors:||Liu, J.
|Issue Date:||7-Mar-2013||Citation:||Liu, J., Li, K., Geng, J., Zhou, L., Chandrasekharan, P., Yang, C.-T., Liu, B. (2013-03-07). Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging. Polymer Chemistry 4 (5) : 1517-1524. ScholarBank@NUS Repository.||Abstract:||We designed and synthesized a gadolinium(iii)-decorated hyperbranched polyglycerol with a fluorescent polyhedral oligomeric silsesquioxane core (POSS-HPG-Gd), and demonstrated its application as a single-molecular nanoprobe for fluorescence and magnetic resonance dual imaging. The nanoprobe exhibited a uniform size with a mean diameter of 6 ± 1 nm revealed by transmission electron microscopy. POSS-HPG-Gd showed absorption and emission maxima at 405 and 570 nm in water, respectively, with a quantum yield of 41 ± 1%. Fluorescence cell imaging by confocal laser scanning microscopy using MCF-7 cancer cells as a model cell line revealed that the nanoprobe had been successfully internalized into the cytoplasm with high brightness, low cytotoxicity and good photostability. Further magnetic resonance imaging study demonstrated that POSS-HPG-Gd can serve as a promising probe for fluorescence and magnetic resonance dual modal imaging. © 2013 The Royal Society of Chemistry.||Source Title:||Polymer Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/64596||ISSN:||17599954|
|Appears in Collections:||Staff Publications|
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