Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja103738t
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dc.titleQuantum dot capped magnetite nanorings as high performance nanoprobe for multiphoton fluorescence and magnetic resonance imaging
dc.contributor.authorFan, H.-M.
dc.contributor.authorOlivo, M.
dc.contributor.authorShuter, B.
dc.contributor.authorYi, J.-B.
dc.contributor.authorBhuvaneswari, R.
dc.contributor.authorTan, H.-R.
dc.contributor.authorXing, G.-C.
dc.contributor.authorNg, C.-T.
dc.contributor.authorLiu, L.
dc.contributor.authorLucky, S.S.
dc.contributor.authorBay, B.-H.
dc.contributor.authorDing, J.
dc.date.accessioned2014-06-17T07:47:47Z
dc.date.available2014-06-17T07:47:47Z
dc.date.issued2010-10-27
dc.identifier.citationFan, H.-M., Olivo, M., Shuter, B., Yi, J.-B., Bhuvaneswari, R., Tan, H.-R., Xing, G.-C., Ng, C.-T., Liu, L., Lucky, S.S., Bay, B.-H., Ding, J. (2010-10-27). Quantum dot capped magnetite nanorings as high performance nanoprobe for multiphoton fluorescence and magnetic resonance imaging. Journal of the American Chemical Society 132 (42) : 14803-14811. ScholarBank@NUS Repository. https://doi.org/10.1021/ja103738t
dc.identifier.issn00027863
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/64484
dc.description.abstractIn the present study, quantum dot (QD) capped magnetite nanorings (NRs) with a high luminescence and magnetic vortex core have been successfully developed as a new class of magnetic-fluorescent nanoprobe. Through electrostatic interaction, cationic polyethylenimine (PEI) capped QD have been firmly graft into negatively charged magnetite NRs modified with citric acid on the surface. The obtained biocompatible multicolor QD capped magnetite NRs exhibit a much stronger magnetic resonance (MR) T2* effect where the r2* relaxivity and r2*/r1 ratio are 4 times and 110 times respectively larger than those of a commercial superparamagnetic iron oxide. The multiphoton fluorescence imaging and cell uptake of QD capped magnetite NRs are also demonstrated using MGH bladder cancer cells. In particular, these QD capped magnetite NRs can escape from endosomes and be released into the cytoplasm. The obtained results from these exploratory experiments suggest that the cell-penetrating QD capped magnetite NRs could be an excellent dual-modality nanoprobe for intracellular imaging and therapeutic applications. This work has shown great potential of the magnetic vortex core based multifunctional nanoparticle as a high performance nanoprobe for biomedical applications. © 2010 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ja103738t
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMATERIALS SCIENCE AND ENGINEERING
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.contributor.departmentPHARMACY
dc.description.doi10.1021/ja103738t
dc.description.sourcetitleJournal of the American Chemical Society
dc.description.volume132
dc.description.issue42
dc.description.page14803-14811
dc.description.codenJACSA
dc.identifier.isiut000283403200029
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