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Title: Poly(dopamine acrylamide)-co-poly(propargyl acrylamide)-modified titanium surfaces for 'click' functionalization
Authors: Xu, L.Q.
Jiang, H.
Neoh, K.-G. 
Kang, E.-T. 
Fu, G.D.
Issue Date: Apr-2012
Citation: Xu, L.Q., Jiang, H., Neoh, K.-G., Kang, E.-T., Fu, G.D. (2012-04). Poly(dopamine acrylamide)-co-poly(propargyl acrylamide)-modified titanium surfaces for 'click' functionalization. Polymer Chemistry 3 (4) : 920-927. ScholarBank@NUS Repository.
Abstract: Poly(dopamine acrylamide)-co-poly(propargyl acrylamide) (PDA-co-PPA) copolymers, containing alkyne- and catechol-functionalities, were prepared from reactive poly(pentafluorophenyl acrylate) (PPFA) via functionalization of the pentafluorophenyl-activated ester groups with dopamine hydrochloride and propargylamine. The bifunctional PDA-co-PPA copolymers were then coupled to the titanium (Ti) surface via coordination interaction of the catechol moieties, yielding a functionalizable Ti platform containing 'clickable' alkyne groups on the surface for the copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) of azide-labeled fluorescein, rhodamine, β-cyclodextrin, poly(ethylene glycol) (PEG), mannose and biotin. The functionalized Ti surfaces from the CuAAC reactions were characterized by fluorescence microscopy (for the rhodamine- and fluorescein-functionalized Ti surfaces), non-specific protein adsorption (for the PEG-grafted Ti surface), specific protein adsorption (for the mannose- and biotin-functionalized Ti surfaces) and host-guest interaction with antibiotics (for the β-cyclodextrin-functionalized Ti surface). © 2012 The Royal Society of Chemistry.
Source Title: Polymer Chemistry
ISSN: 17599954
DOI: 10.1039/c2py00552b
Appears in Collections:Staff Publications

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