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Title: PAT-enabled determination of design space for seeded cooling crystallization
Authors: Yu, Z.Q.
Chow, P.S.
Tan, R.B.H. 
Ang, W.H.
Issue Date: 15-Mar-2013
Citation: Yu, Z.Q., Chow, P.S., Tan, R.B.H., Ang, W.H. (2013-03-15). PAT-enabled determination of design space for seeded cooling crystallization. Organic Process Research and Development 17 (3) : 549-556. ScholarBank@NUS Repository.
Abstract: A simple and practical procedure to facilitate the determination of the design space for seeded cooling crystallization is proposed and demonstrated. Solute supersaturation is used as an effective link between six operational process factors and a chosen critical quality attribute, namely, fines fraction in the crystal product. A semi-mechanistic process model is developed, which accounts for the dynamics of supersaturation via moments of particle size distribution. ATR-FTIR and FBRM data from three batches for the model system myo-inositol dihydrate in water were used to estimate and update the model parameters, and the design space was verified experimentally in a subsequent run. © 2013 American Chemical Society.
Source Title: Organic Process Research and Development
ISSN: 10836160
DOI: 10.1021/op300319t
Appears in Collections:Staff Publications

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