Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/64308
DC Field | Value | |
---|---|---|
dc.title | Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements | |
dc.contributor.author | Zhou, Z. | |
dc.contributor.author | Xiao, Y. | |
dc.contributor.author | Hatton, T.A. | |
dc.contributor.author | Chung, T.-S. | |
dc.date.accessioned | 2014-06-17T07:45:40Z | |
dc.date.available | 2014-06-17T07:45:40Z | |
dc.date.issued | 2011-05 | |
dc.identifier.citation | Zhou, Z., Xiao, Y., Hatton, T.A., Chung, T.-S. (2011-05). Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements. AIChE Journal 57 (5) : 1154-1162. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00011541 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/64308 | |
dc.description.abstract | Novel membrane processes for the effective enantioresolution of racemic mixtures have been evaluated. The incorporation of human serum albumin (HSA) in the strip solution of a permeation cell resulted in the partial optical resolution of a racemic tryptophan mixture, as the permeation of L-tryptophan, which binds to HSA more strongly, was enhanced selectively over that of D-tryptophan. A second approach in which a racemic mixture was introduced to the strip solution prior to the experiments showed better performance by selectively decreasing the flux of the more weakly bound D-tryptophan. The highest enantioselectivity of ~9.76 was achieved with a third, novel design consisting of two permeation cells in series, which can encompass the advantages of affinity dialysis. An industrial scale unit is proposed based on this concept and a suitably validated mathematical model. Copyright © 2010 American Institute of Chemical Engineers (AIChE). | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/aic.12336 | |
dc.source | Scopus | |
dc.subject | Chiral separation | |
dc.subject | Enantiomers | |
dc.subject | Human serum albumin | |
dc.subject | Membrane separation | |
dc.subject | Selective permeation enhancement | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.sourcetitle | AIChE Journal | |
dc.description.volume | 57 | |
dc.description.issue | 5 | |
dc.description.page | 1154-1162 | |
dc.description.coden | AICEA | |
dc.identifier.isiut | 000289532700005 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.