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Title: Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements
Authors: Zhou, Z.
Xiao, Y. 
Hatton, T.A.
Chung, T.-S.
Keywords: Chiral separation
Human serum albumin
Membrane separation
Selective permeation enhancement
Issue Date: May-2011
Citation: Zhou, Z., Xiao, Y., Hatton, T.A., Chung, T.-S. (2011-05). Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements. AIChE Journal 57 (5) : 1154-1162. ScholarBank@NUS Repository.
Abstract: Novel membrane processes for the effective enantioresolution of racemic mixtures have been evaluated. The incorporation of human serum albumin (HSA) in the strip solution of a permeation cell resulted in the partial optical resolution of a racemic tryptophan mixture, as the permeation of L-tryptophan, which binds to HSA more strongly, was enhanced selectively over that of D-tryptophan. A second approach in which a racemic mixture was introduced to the strip solution prior to the experiments showed better performance by selectively decreasing the flux of the more weakly bound D-tryptophan. The highest enantioselectivity of ~9.76 was achieved with a third, novel design consisting of two permeation cells in series, which can encompass the advantages of affinity dialysis. An industrial scale unit is proposed based on this concept and a suitably validated mathematical model. Copyright © 2010 American Institute of Chemical Engineers (AIChE).
Source Title: AIChE Journal
ISSN: 00011541
Appears in Collections:Staff Publications

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