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|Title:||Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements||Authors:||Zhou, Z.
Human serum albumin
Selective permeation enhancement
|Issue Date:||May-2011||Citation:||Zhou, Z., Xiao, Y., Hatton, T.A., Chung, T.-S. (2011-05). Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements. AIChE Journal 57 (5) : 1154-1162. ScholarBank@NUS Repository.||Abstract:||Novel membrane processes for the effective enantioresolution of racemic mixtures have been evaluated. The incorporation of human serum albumin (HSA) in the strip solution of a permeation cell resulted in the partial optical resolution of a racemic tryptophan mixture, as the permeation of L-tryptophan, which binds to HSA more strongly, was enhanced selectively over that of D-tryptophan. A second approach in which a racemic mixture was introduced to the strip solution prior to the experiments showed better performance by selectively decreasing the flux of the more weakly bound D-tryptophan. The highest enantioselectivity of ~9.76 was achieved with a third, novel design consisting of two permeation cells in series, which can encompass the advantages of affinity dialysis. An industrial scale unit is proposed based on this concept and a suitably validated mathematical model. Copyright © 2010 American Institute of Chemical Engineers (AIChE).||Source Title:||AIChE Journal||URI:||http://scholarbank.nus.edu.sg/handle/10635/64308||ISSN:||00011541|
|Appears in Collections:||Staff Publications|
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