Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.09.024
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dc.titleIn vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles
dc.contributor.authorLi, J.-L.
dc.contributor.authorWang, L.
dc.contributor.authorLiu, X.-Y.
dc.contributor.authorZhang, Z.-P.
dc.contributor.authorGuo, H.-C.
dc.contributor.authorLiu, W.-M.
dc.contributor.authorTang, S.-H.
dc.date.accessioned2014-06-17T07:43:08Z
dc.date.available2014-06-17T07:43:08Z
dc.date.issued2009-02-18
dc.identifier.citationLi, J.-L., Wang, L., Liu, X.-Y., Zhang, Z.-P., Guo, H.-C., Liu, W.-M., Tang, S.-H. (2009-02-18). In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles. Cancer Letters 274 (2) : 319-326. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.09.024
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/64089
dc.description.abstractGold nanoparticles were conjugated with transferrin molecules for targeting, imaging and therapy of breast cancer cells (Hs578T, ATCC). Results show that, the transferrin-transferrin receptor-mediated cellular uptake of gold nanoparticles is six times of that in the absence of this interaction. As a consequence, the laser power effective for photothermal therapy of the cancer cells was reduced to values of two orders of magnitude lower. To demonstrate the efficiency of the conjugated gold nanoparticles in selectively targeting cancer cells, the cellular uptake of the gold nanoparticles by noncancerous cells (3T3, ATCC) was also investigated. The cellular uptake by the normal cells is only one fourth of that by the cancerous cells indicating that the transferrin-transferrin receptor interaction plays an important role in controlling the cellular uptake of the gold nanoparticles. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2008.09.024
dc.sourceScopus
dc.subjectCell
dc.subjectGold nanoparticle
dc.subjectImaging and therapy
dc.subjectIn vitro
dc.subjectTransferrin
dc.typeArticle
dc.contributor.departmentNUS NANOSCIENCE & NANOTECH INITIATIVE
dc.contributor.departmentPHYSICS
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.canlet.2008.09.024
dc.description.sourcetitleCancer Letters
dc.description.volume274
dc.description.issue2
dc.description.page319-326
dc.description.codenCALED
dc.identifier.isiut000263206100020
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