Please use this identifier to cite or link to this item:
Title: High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact
Authors: Kwek, J.W.
Heng, D.
Lee, S.H.
Ng, W.K.
Chan, H.-K.
Adi, S.
Heng, J.
Tan, R.B.H. 
Keywords: De-agglomeration
High speed imaging
Surface roughness
Issue Date: Nov-2013
Citation: Kwek, J.W., Heng, D., Lee, S.H., Ng, W.K., Chan, H.-K., Adi, S., Heng, J., Tan, R.B.H. (2013-11). High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact. Journal of Aerosol Science 65 : 77-87. ScholarBank@NUS Repository.
Abstract: A dry powder inhaler (DPI) is effective in treating respiratory diseases if it can deliver consistent and reliable drug dosage with each actuation. De-agglomeration and subsequent detachment of the drug from the carrier particles upon actuation depends on the interaction forces between particle and wall and particles themselves. The particle surface properties such as roughness and moisture sorption, in turn, determine the extent of the interactions. Via combining high speed imaging with non-intrusive electrostatic measurements in an impaction throat model, the contributions of the electrostatic forces arising from de-agglomeration and impaction behaviours of the rough and smooth particulates could be investigated at 60. L/min. Higher flowing charges with limited agglomerate fracture upon impaction were observed for the rough carrier particles while significant agglomerate breakup and 'plume-like' re-entrainment behaviour was noted for the smooth ones. Increased moisture sorption on the larger specific surface area of the rough particles could have facilitated the accumulation of surface charges while the higher dispersive surface energy could have increased the cohesiveness of the rough particles. The smooth particles easily broke up upon impaction. High speed imaging with electrostatic monitoring has proved to be useful in investigating the mechanisms of powder de-agglomeration upon impaction. © 2013 Elsevier Ltd.
Source Title: Journal of Aerosol Science
ISSN: 00218502
DOI: 10.1016/j.jaerosci.2013.07.011
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Oct 14, 2021


checked on Oct 14, 2021

Page view(s)

checked on Oct 14, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.