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Title: Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes
Authors: Zhao, Y.
Howe, J.L.C.
Yu, Z.
Leong, D.T. 
Chu, J.J.H.
Loo, J.S.C.
Ng, K.W.
Keywords: autophagy
titanium dioxide
Issue Date: 11-Feb-2013
Citation: Zhao, Y., Howe, J.L.C., Yu, Z., Leong, D.T., Chu, J.J.H., Loo, J.S.C., Ng, K.W. (2013-02-11). Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes. Small 9 (3) : 387-392. ScholarBank@NUS Repository.
Abstract: Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
ISSN: 16136810
DOI: 10.1002/smll.201201363
Appears in Collections:Staff Publications

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