Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jcis.2006.06.037
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dc.titleElectrohydrodynamic atomization for biodegradable polymeric particle production
dc.contributor.authorXie, J.
dc.contributor.authorLim, L.K.
dc.contributor.authorPhua, Y.
dc.contributor.authorHua, J.
dc.contributor.authorWang, C.-H.
dc.date.accessioned2014-06-17T07:39:48Z
dc.date.available2014-06-17T07:39:48Z
dc.date.issued2006-10-01
dc.identifier.citationXie, J., Lim, L.K., Phua, Y., Hua, J., Wang, C.-H. (2006-10-01). Electrohydrodynamic atomization for biodegradable polymeric particle production. Journal of Colloid and Interface Science 302 (1) : 103-112. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jcis.2006.06.037
dc.identifier.issn00219797
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63810
dc.description.abstractElectrohydrodynamic atomization (EHDA) has many applications such as electrospray ionization in mass spectroscopy, electrospray deposition of thin films, pharmaceutical productions, and polymeric particle fabrications for drug encapsulation. In the present study, EHDA was employed to produce biodegradable polymeric micro- and nanoparticles. The effects of processing parameters such as polymer concentration, flow rate, surfactants, organic salt, and setup configurations on the size and morphology of polymeric particles were investigated systematically. By changing the various processing parameters, controllable particle shape and size can be achieved. PLGA nanoparticles with size of around 250 nm can be obtained by using organic salts to increase the conductivity of the spraying solution even at a relatively high flow rate. A higher flow rate has the advantage of producing a stable cone spray and can be easily reproduced. Solid and porous particles can be fabricated using different experimental setups to control the organic solvent evaporation rate. Also, paclitaxel, a model antineoplastic drug, was encapsulated in polymeric particles which can be employed for controlled release applications. In short, EHDA is a promising technique to fabricate polymeric micro- or nanoparticles which can be used in drug delivery systems. © 2006 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jcis.2006.06.037
dc.sourceScopus
dc.subjectBiodegradable
dc.subjectElectrohydrodynamic atomization
dc.subjectMicroparticles
dc.subjectNanoparticles
dc.subjectPolymeric
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.jcis.2006.06.037
dc.description.sourcetitleJournal of Colloid and Interface Science
dc.description.volume302
dc.description.issue1
dc.description.page103-112
dc.description.codenJCISA
dc.identifier.isiut000240667800013
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