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Title: Efficient epoxidation of alkenes with hydrogen peroxide, lactone, and lipase
Authors: Xu, Y. 
Khaw, N.R.B.J.
Li, Z. 
Issue Date: 2009
Citation: Xu, Y., Khaw, N.R.B.J., Li, Z. (2009). Efficient epoxidation of alkenes with hydrogen peroxide, lactone, and lipase. Green Chemistry 11 (12) : 2047-2051. ScholarBank@NUS Repository.
Abstract: A green and efficient oxidation system containing hydrogen peroxide, lactone, and lipase was developed for the epoxidation of alkenes. A variety of alkenes was oxidized with this system, giving 87-95% analytical yield of the corresponding epoxides. The epoxidation occurred via lipase-catalyzed formation of hydroxy peroxy acid from lactone, without release of any harmful short-chain acid and alcohol, and in situ chemical oxidation of alkenes. Both hydrophilic ε-caprolactone and hydrophobic δ-decanolactone were shown to be good substrates to produce hydroxy peracids and good reaction solvents, and the method is suitable for the oxidation in either single phase or two-liquid phase. In comparison with other lipase-mediated oxidation systems, the new oxidation system gave higher yield, higher efficiency, and higher enzyme stability. © 2009 The Royal Society of Chemistry.
Source Title: Green Chemistry
ISSN: 14639262
DOI: 10.1039/b913077b
Appears in Collections:Staff Publications

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