Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ces.2004.03.014
DC FieldValue
dc.titleEffects of adsorption kinetics and surface heterogeneity on band spreading in perfusion chromatography - A network model analysis
dc.contributor.authorGeng, A.
dc.contributor.authorLoh, K.-C.
dc.date.accessioned2014-06-17T07:39:25Z
dc.date.available2014-06-17T07:39:25Z
dc.date.issued2004-06
dc.identifier.citationGeng, A., Loh, K.-C. (2004-06). Effects of adsorption kinetics and surface heterogeneity on band spreading in perfusion chromatography - A network model analysis. Chemical Engineering Science 59 (12) : 2447-2456. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ces.2004.03.014
dc.identifier.issn00092509
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63775
dc.description.abstractA network model was used to simulate the band-spreading of an eluting solute from a perfusive column under retained conditions. The computer experiments were carried out over a wide range of Peclet numbers. The effects of pore size distribution (PSD), pore inter-connectivity and linear adsorption/desorption kinetics were taken into account in the simulations. Surface heterogeneity effects were also discussed. Among these parameters investigated, adsorption/desorption kinetics was the most important parameter, which influenced the transit-time moments and, in turn, the band-spreading as well as band-tailing results significantly over the whole range of Peclet numbers investigated. In addition, pore inter-connectivity and PSD also play an important role in determining the band-spreading results. However, their effects are only important in the molecular diffusion- and convection-controlled regimes. Under strongly retained conditions, contribution of hydrodynamics can be neglected. Furthermore, surface energetic heterogeneity resulting from the wide pore size distributions could exacerbate both band spreading and band tailing; the effects on band tailing being more significant than those on band spreading. © 2004 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ces.2004.03.014
dc.sourceScopus
dc.subjectAdsorption/desorption kinetics
dc.subjectBand spreading
dc.subjectHETP
dc.subjectNetwork modelling
dc.subjectPerfusion chromatography
dc.subjectSurface heterogeneity
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.ces.2004.03.014
dc.description.sourcetitleChemical Engineering Science
dc.description.volume59
dc.description.issue12
dc.description.page2447-2456
dc.description.codenCESCA
dc.identifier.isiut000221924700009
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