Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bios.2007.12.012
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dc.titleDevelopment of electrochemical calcium sensors by using silicon nanowires modified with phosphotyrosine
dc.contributor.authorBi, X.
dc.contributor.authorWong, W.L.
dc.contributor.authorJi, W.
dc.contributor.authorAgarwal, A.
dc.contributor.authorBalasubramanian, N.
dc.contributor.authorYang, K.-L.
dc.date.accessioned2014-06-17T07:38:46Z
dc.date.available2014-06-17T07:38:46Z
dc.date.issued2008-05-15
dc.identifier.citationBi, X., Wong, W.L., Ji, W., Agarwal, A., Balasubramanian, N., Yang, K.-L. (2008-05-15). Development of electrochemical calcium sensors by using silicon nanowires modified with phosphotyrosine. Biosensors and Bioelectronics 23 (10) : 1442-1448. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bios.2007.12.012
dc.identifier.issn09565663
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63721
dc.description.abstractThis paper reports the electrical detection of calcium ions by using silicon nanowires (SiNWs) as channels in a chemically gated field-effect-transistor (FET) configuration. To obtain a selective and sensitive layer for calcium sensing, the SiNWs are modified with a biologically relevant amino acid phosphotyrosine (p-Tyr), which is able to complex calcium ions with high affinity. It is found that when the p-Tyr modified SiNWs are exposed to aqueous solutions containing calcium ions, their conductances increase with the increasing of calcium concentration up to 10 μM. In contrast, when the SiNWs are exposed to sodium or potassium, or when they are modified with tyrosine (Tyr), no significant increase in the conductance is observed. This finding suggests that the calcium ions complexed with the phosphate group of p-Tyr can act as a positive gate voltage on the FET device comprising of n-type SiNWs, and leads to an increase in their conductances. The FET device is also sensitive to magnesium ions. However, the response is 10 times lower than that of calcium at the same concentration. The study reported here may pave the way for designing an intracellular calcium sensor which permits the monitoring of calcium concentration in real time. © 2007 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bios.2007.12.012
dc.sourceScopus
dc.subjectCalcium sensors
dc.subjectElectrochemical
dc.subjectField-effect-transistor
dc.subjectPhosphotyrosine
dc.subjectSilicon nanowire
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.bios.2007.12.012
dc.description.sourcetitleBiosensors and Bioelectronics
dc.description.volume23
dc.description.issue10
dc.description.page1442-1448
dc.description.codenBBIOE
dc.identifier.isiut000255793200005
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