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Title: Complexation of cationic polyelectrolyte with anionic phospholipid vesicles: Concentration, molecular weight and salt effects
Authors: Chieng, Y.Y.
Chen, S.B. 
Keywords: Charge
Issue Date: 1-Feb-2011
Citation: Chieng, Y.Y., Chen, S.B. (2011-02-01). Complexation of cationic polyelectrolyte with anionic phospholipid vesicles: Concentration, molecular weight and salt effects. Journal of Colloid and Interface Science 354 (1) : 226-233. ScholarBank@NUS Repository.
Abstract: The influence of cationic poly(diallyldimethylammonium chloride) on the morphology and phase behavior of anionic phospholipid vesicles was investigated using differential scanning calorimetry, fluorescent microscopy and light scattering technique. A wide range of polymer concentration has been examined for the first time. The polycation can bind electrostatically to the vesicles to compensate, neutralize and reverse the vesicular charge, depending on the molar ratio of cationic to anionic group R. For R< 1, charge compensation weakened the electrostatic repulsion between the lipid molecules, leading to formation of polymer-modified vesicles, each with an increased number of bilayers. The bilayer exhibits a rising main phase transition temperature from a gel to liquid crystalline state. This behavior persisted until R≈ 1 around the neutralization condition, where the complexes became largest and precipitate. With R> 1, charge reversal took place, the complex size reduced. Interestingly, the main phase transition temperature was found for the first time to shift back towards the original value in the absence of polymer for large enough R. Although the thermal behavior was nearly independent of the polymer molecular weight, the complex morphology could be different. © 2010 Elsevier Inc.
Source Title: Journal of Colloid and Interface Science
ISSN: 00219797
DOI: 10.1016/j.jcis.2010.10.045
Appears in Collections:Staff Publications

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