Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11426-013-4936-3
DC FieldValue
dc.titleBiocompatible organic dots with aggregation-induced emission for in vitro and in vivo fluorescence imaging
dc.contributor.authorLi, K.
dc.contributor.authorDing, D.
dc.contributor.authorZhao, Q.
dc.contributor.authorSun, J.
dc.contributor.authorTang, B.Z.
dc.contributor.authorLiu, B.
dc.date.accessioned2014-06-17T07:36:36Z
dc.date.available2014-06-17T07:36:36Z
dc.date.issued2013-09
dc.identifier.citationLi, K., Ding, D., Zhao, Q., Sun, J., Tang, B.Z., Liu, B. (2013-09). Biocompatible organic dots with aggregation-induced emission for in vitro and in vivo fluorescence imaging. Science China Chemistry 56 (9) : 1228-1233. ScholarBank@NUS Repository. https://doi.org/10.1007/s11426-013-4936-3
dc.identifier.issn16747291
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63535
dc.description.abstractFluorescent probes play a key role in modern biomedical research. As compared to inorganic quantum dots (QDs) composed with heavy metal elements, organic dye-based fluorescent nanoparticles have higher biocompatibility and are richer in variety. However, traditional organic fluorophores tend to quench fluorescence upon aggregation, which is known as aggregation-caused quenching (ACQ) effect that hinders the fabrication of highly emissive fluorescent nanoparticles. In this work, we demonstrate the synthesis of organic fluorescent dots with aggregation-induced emission (AIE) in far-red/near-infrared (FA/NIR) region. A conventional ACQ-characteristic fluorescent dye, 3,4:9,10- tetracarboxylic perylene bisimide (PBI), is converted into an AIE fluorogen through attaching two tetraphenylethylene (TPE) moieties. The fluorescent dots with surface folic acid groups are fabricated from PBI derivative (DTPEPBI), showing specific targeting effect to folate receptor-overexpressed cancer cells. In vivo studies also suggest that the folic acid-functionalized AIE dots preferentially accumulate in the tumor site through enhanced permeability and retention (EPR) effect and folate receptor-mediated active targeting effect. The low cytotoxicity, good FR/NIR contrast and excellent targeting ability in in vitro/in vivo imaging indicate that the AIE dots have great potentials in advanced bioimaging applications. © 2013 Science China Press and Springer-Verlag Berlin Heidelberg.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s11426-013-4936-3
dc.sourceScopus
dc.subjectaggregation-induced emission
dc.subjectAIE dots
dc.subjectfluorescence imaging
dc.subjecttargeted imaging
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1007/s11426-013-4936-3
dc.description.sourcetitleScience China Chemistry
dc.description.volume56
dc.description.issue9
dc.description.page1228-1233
dc.description.codenSCCCC
dc.identifier.isiut000323505300011
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

35
checked on Nov 24, 2020

WEB OF SCIENCETM
Citations

32
checked on Nov 24, 2020

Page view(s)

97
checked on Nov 30, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.