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https://doi.org/10.1007/s00449-008-0226-4
Title: | An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins | Authors: | Yusufi, F.N.K. Park, W. Lee, M.M. Lee, D.-Y. |
Keywords: | Alpha-numeric code Data exchange format Glycomics N-linked glycans Recombinant glycoproteins |
Issue Date: | Jan-2009 | Citation: | Yusufi, F.N.K., Park, W., Lee, M.M., Lee, D.-Y. (2009-01). An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins. Bioprocess and Biosystems Engineering 32 (1) : 97-107. ScholarBank@NUS Repository. https://doi.org/10.1007/s00449-008-0226-4 | Abstract: | Advances in high-throughput techniques have led to the creation of increasing amounts of glycome data. The storage and analysis of this data would benefit greatly from a compact notation for describing glycan structures that can be easily stored and interpreted by computers. Towards this end, we propose a fixed-length alpha-numeric code for representing N-linked glycan structures commonly found in secreted glycoproteins from mammalian cell cultures. This code, GlycoDigit, employs a pre-assigned alpha-numeric index to represent the monosaccharides attached in different branches to the core glycan structure. The present branch-centric representation allows us to visualize the structure while the numerical nature of the code makes it machine readable. In addition, a difference operator can be defined to quantitatively differentiate between glycan structures for further analysis. The usefulness and applicability of GlycoDigit were demonstrated by constructing and visualizing an N-linked glycosylation network. © 2008 Springer-Verlag. | Source Title: | Bioprocess and Biosystems Engineering | URI: | http://scholarbank.nus.edu.sg/handle/10635/63461 | ISSN: | 16157591 | DOI: | 10.1007/s00449-008-0226-4 |
Appears in Collections: | Staff Publications |
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