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Title: An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins
Authors: Yusufi, F.N.K.
Park, W.
Lee, M.M.
Lee, D.-Y. 
Keywords: Alpha-numeric code
Data exchange format
N-linked glycans
Recombinant glycoproteins
Issue Date: Jan-2009
Citation: Yusufi, F.N.K., Park, W., Lee, M.M., Lee, D.-Y. (2009-01). An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins. Bioprocess and Biosystems Engineering 32 (1) : 97-107. ScholarBank@NUS Repository.
Abstract: Advances in high-throughput techniques have led to the creation of increasing amounts of glycome data. The storage and analysis of this data would benefit greatly from a compact notation for describing glycan structures that can be easily stored and interpreted by computers. Towards this end, we propose a fixed-length alpha-numeric code for representing N-linked glycan structures commonly found in secreted glycoproteins from mammalian cell cultures. This code, GlycoDigit, employs a pre-assigned alpha-numeric index to represent the monosaccharides attached in different branches to the core glycan structure. The present branch-centric representation allows us to visualize the structure while the numerical nature of the code makes it machine readable. In addition, a difference operator can be defined to quantitatively differentiate between glycan structures for further analysis. The usefulness and applicability of GlycoDigit were demonstrated by constructing and visualizing an N-linked glycosylation network. © 2008 Springer-Verlag.
Source Title: Bioprocess and Biosystems Engineering
ISSN: 16157591
DOI: 10.1007/s00449-008-0226-4
Appears in Collections:Staff Publications

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