Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2jm31368e
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dc.titleAggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging
dc.contributor.authorZhao, Q.
dc.contributor.authorLi, K.
dc.contributor.authorChen, S.
dc.contributor.authorQin, A.
dc.contributor.authorDing, D.
dc.contributor.authorZhang, S.
dc.contributor.authorLiu, Y.
dc.contributor.authorLiu, B.
dc.contributor.authorSun, J.Z.
dc.contributor.authorTang, B.Z.
dc.date.accessioned2014-06-17T07:35:39Z
dc.date.available2014-06-17T07:35:39Z
dc.date.issued2012-08-14
dc.identifier.citationZhao, Q., Li, K., Chen, S., Qin, A., Ding, D., Zhang, S., Liu, Y., Liu, B., Sun, J.Z., Tang, B.Z. (2012-08-14). Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging. Journal of Materials Chemistry 22 (30) : 15128-15135. ScholarBank@NUS Repository. https://doi.org/10.1039/c2jm31368e
dc.identifier.issn09599428
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/63453
dc.description.abstractOrganic fluorescent probes are widely used in bioimaging and bioassays, but the notorious photobleaching hampers their applications. Encapsulation of organic dyes into nanoparticles (NPs) is an effective strategy to minimize photobleaching, but classical organic dye molecules tend to have their fluorescence quenched in aggregate states, which is termed aggregation-caused quenching (ACQ). Here we demonstrate our attempt to tackle this problem through the aggregation-induced emission (AIE) strategy. 3,4:9,10-Tetracarboxylic perylene bisimide (PBI) is a well-known organic dye with a serious ACQ problem. By attaching two tetraphenylethene (TPE) moieties to the 1,7-positions, the ACQ-characteristic PBI-derivative was converted to an AIE-characteristic molecule. The obtained PBI derivative (BTPEPBI) exhibits several advantages over classical PBI derivatives, including pronounced fluorescence enhancement in aggregate state, red to near infrared emission, and facile fabrication into uniform NPs. Studies on the staining of MCF-7 breast cancer cells and in vivo imaging of a tumor-bearing mouse model with BTPEPBI-containing NPs reveal that they are effective fluorescent probes for cancer cell and in vivo tumor diagnosis with high specificity, high photostability and good fluorescence contrast. This journal is © The Royal Society of Chemistry 2012.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c2jm31368e
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c2jm31368e
dc.description.sourcetitleJournal of Materials Chemistry
dc.description.volume22
dc.description.issue30
dc.description.page15128-15135
dc.description.codenJMACE
dc.identifier.isiut000306215900046
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