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|Title:||Surface modification of magnetron-sputtered hydroxyapatite thin films via silicon substitution for orthopaedic and dental applications||Authors:||Thian, E.S.
|Issue Date:||25-Feb-2011||Citation:||Thian, E.S., Huang, J., Barber, Z.H., Best, S.M., Bonfield, W. (2011-02-25). Surface modification of magnetron-sputtered hydroxyapatite thin films via silicon substitution for orthopaedic and dental applications. Surface and Coatings Technology 205 (11) : 3472-3477. ScholarBank@NUS Repository. https://doi.org/10.1016/j.surfcoat.2010.12.012||Abstract:||There have been a significant advances made in the field of bioceramics, particularly hydroxyapatite (HA) during the past 10 years. Emphasis has now shifted towards designing HA with enhanced bioactivity for bone tissue repair. The aim of this study was to assess whether surface wettability can be correlated with cellular interactions with silicon-substituted hydroxyapatite (SiHA)-coated titanium (Ti) substrates. SiHA thin coatings of varying Si compositions were deposited on Ti substrates via a magnetron co-sputtering technique. These coatings were then subjected to an in vitro study using primary human ostoeblast (HOB) cells, to evaluate their biological property. HOB cells showed initial poor adhesion and spreading on hydrophobic Ti surface. The application of HA or SiHA thin coatings on Ti substrates by magnetron co-sputtering technique renders the surface more hydrophilic, with water contact angles between 30 and 40°. HOB cells attached, spread and proliferated well on these coatings. Enhanced calcification (formation of calcium phosphate nodules across the collagenous matrices) was observed on SiHA coatings with increasing Si content. This interdisciplinary paper highlighted that enhanced bioactivity was associated with surface wettability. Producing a nanostructured HA coating on a Ti substrate by magnetron sputtering resulted in the promotion of cell proliferation and calcification, and the latter was further enhanced with Si substitution. Hence, SiHA thin coating holds great potential as an alternative dental material. © 2010 Elsevier B.V.||Source Title:||Surface and Coatings Technology||URI:||http://scholarbank.nus.edu.sg/handle/10635/61429||ISSN:||02578972||DOI:||10.1016/j.surfcoat.2010.12.012|
|Appears in Collections:||Staff Publications|
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