Please use this identifier to cite or link to this item: https://doi.org/10.1142/S0218339004001300
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dc.titleRole of phenergan in abnormal scars and keloids
dc.contributor.authorVenugopal, J.
dc.contributor.authorJayaraman, V.
dc.contributor.authorBabu, M.
dc.contributor.authorRamakrishna, S.
dc.date.accessioned2014-06-17T06:32:49Z
dc.date.available2014-06-17T06:32:49Z
dc.date.issued2004-12
dc.identifier.citationVenugopal, J., Jayaraman, V., Babu, M., Ramakrishna, S. (2004-12). Role of phenergan in abnormal scars and keloids. Journal of Biological Systems 12 (4) : 471-482. ScholarBank@NUS Repository. https://doi.org/10.1142/S0218339004001300
dc.identifier.issn02183390
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/61249
dc.description.abstractHypertrophic scar and keloids have affected patients and frustrated physicians for centuries. Hypertrophic scar (HSc) and keloids are a major problem for patients who survive extensive thermal and traumatic skin injuries. HSc and other fibroproliferative disorders are associated with excessive accumulation of collagen and extracellular matrix proteins due to an imbalance between synthesis and degradation. The therapeutic management of hypertrophic scars and keloids include occlusive dressings, compression therapy, intralesional corticosteroid injections, cryosurgery, excision, radiation therapy, laser therapy, interferon therapy and other promising lesser known therapies directed at collagen synthesis. In this study we investigated the effect of phenergan (promethazine hydrochloride) as one of the most potent histamine antagonists on cell proliferation, DNA synthesis and collagen production in fibroblast isolated from human post burn hypertrophic scar, keloids and normal skin. The proliferation of normal skin fibroblast was slightly decreased but hypertrophic scar and keloids showed significant (p < 0.001) level of decrease after 72 hours of phenergan (750 μM) treatment. The results of DNA synthesis also significantly (p < 0.001) decreased in hypertrophic scar and keloid fibroblasts. Phenergan (1.5 mM) decreased the collagen synthesis upto 61% and 66% in HSc and keloids in comparison to normal skin fibroblast, which showed reduction of 38% after 72 hours. Improved understanding of such regulatory mechanisms may eventually be of therapeutic significance in the control of hypertrophic scar and keloids.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1142/S0218339004001300
dc.sourceScopus
dc.subjectCollagen
dc.subjectHypertrophic scar
dc.subjectKeloid
dc.subjectPhenergan
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1142/S0218339004001300
dc.description.sourcetitleJournal of Biological Systems
dc.description.volume12
dc.description.issue4
dc.description.page471-482
dc.identifier.isiut000226175300006
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