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Title: Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration
Authors: Krishnan, R.
Rajeswari, R.
Venugopal, J.
Sundarrajan, S. 
Sridhar, R.
Shayanti, M.
Ramakrishna, S. 
Issue Date: Jun-2012
Citation: Krishnan, R., Rajeswari, R., Venugopal, J., Sundarrajan, S., Sridhar, R., Shayanti, M., Ramakrishna, S. (2012-06). Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration. Journal of Materials Science: Materials in Medicine 23 (6) : 1511-1519. ScholarBank@NUS Repository.
Abstract: Tissue engineering and nanotechnology have advanced a general strategy combining the cellular elements of living tissue with sophisticated functional biocomposites to produce living structures of sufficient size and function at a low cost for clinical relevance. Xylan, a natural polysaccharide was electrospun along with polyvinyl alcohol (PVA) to produce Xylan/PVA nanofibers for skin tissue engineering. The Xylan/PVA glutaraldehyde (Glu) vapor cross-linked nanofibers were characterized by SEM, FT-IR, tensile testing and water contact angle measurements to analyze the morphology, functional groups, mechanical properties and wettability of the fibers for skin tissue regeneration. The cell-biomaterial interactions were studied by culturing human foreskin fibroblasts on Xylan/ PVA Glu vapor cross-linked and Xylan/PVA/Glu blend nanofibrous scaffolds. The observed results showed that the mechanical properties (72 %) and fibroblast proliferation significantly increased up to 23 % (P < 0.05) in 48 h Glu vapor cross-linked nanofibers compared to 24 h Glu vapor cross-linked Xylan/PVA nanofibers. The present study may prove that the natural biodegradable Xylan/PVA nanofibrous scaffolds have good potential for fibroblast adhesion, proliferation and cell matrix interactions relevant for skin tissue regeneration. © Springer Science+Business Media, LLC 2012.
Source Title: Journal of Materials Science: Materials in Medicine
ISSN: 09574530
DOI: 10.1007/s10856-012-4630-6
Appears in Collections:Staff Publications

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