Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.compfluid.2011.05.016
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dc.titleMuco-ciliary transport: Effect of mucus viscosity, cilia beat frequency and cilia density
dc.contributor.authorLee, W.L.
dc.contributor.authorJayathilake, P.G.
dc.contributor.authorTan, Z.
dc.contributor.authorLe, D.V.
dc.contributor.authorLee, H.P.
dc.contributor.authorKhoo, B.C.
dc.date.accessioned2014-06-17T06:27:54Z
dc.date.available2014-06-17T06:27:54Z
dc.date.issued2011-10
dc.identifier.citationLee, W.L., Jayathilake, P.G., Tan, Z., Le, D.V., Lee, H.P., Khoo, B.C. (2011-10). Muco-ciliary transport: Effect of mucus viscosity, cilia beat frequency and cilia density. Computers and Fluids 49 (1) : 214-221. ScholarBank@NUS Repository. https://doi.org/10.1016/j.compfluid.2011.05.016
dc.identifier.issn00457930
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/60836
dc.description.abstractIn this paper, a two-layer Newtonian fluid model consisting of an upper mucus layer and a lower periciliary layer (PCL) is developed to simulate the muco-ciliary transport process. The objective is to investigate the important factors that may affect the muco-ciliary transport and to understand better the underlying mechanics of some respiratory diseases such as cystic fibrosis. The numerical technique implemented in this study is the projection method combined with the Immersed Boundary Method (IBM) for prescribed ciliary beating patterns. A systematic study of the muco-ciliary transport measured in terms of the mean mucus velocity is performed by changing (i) the viscosity of the mucus, (ii) the cilia beat frequency, (iii) the numbers of cilia, (iv) the thickness of PCL, and (v) the surface tension at the interface between the mucus and PCL. We conclude that the cilia beat frequency, the number of cilia, and the depth of PCL are the critical factors affecting the muco-ciliary transport. Moreover, the present results show that the velocity of mucus layer will be reduced when the length of cilia is larger than the depth of PCL. © 2011.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.compfluid.2011.05.016
dc.sourceScopus
dc.subjectCilia
dc.subjectImmersed Boundary Method
dc.subjectMuco-ciliary transport
dc.subjectMucus
dc.typeArticle
dc.contributor.departmentSINGAPORE-MIT ALLIANCE
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.compfluid.2011.05.016
dc.description.sourcetitleComputers and Fluids
dc.description.volume49
dc.description.issue1
dc.description.page214-221
dc.description.codenCPFLB
dc.identifier.isiut000293941100020
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