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Title: Modeling of hemodynamics arising from malaria infection
Authors: Imai, Y.
Kondo, H.
Ishikawa, T.
Teck Lim, C. 
Yamaguchi, T.
Keywords: Blood flow
Computational fluid dynamics
Particle method
Plasmodium falciparum
Red blood cell
Issue Date: May-2010
Citation: Imai, Y., Kondo, H., Ishikawa, T., Teck Lim, C., Yamaguchi, T. (2010-05). Modeling of hemodynamics arising from malaria infection. Journal of Biomechanics 43 (7) : 1386-1393. ScholarBank@NUS Repository.
Abstract: We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles. A two-dimensional spring network of membrane particles is employed for expressing the deformation of malaria infected red blood cells (IRBCs). Malaria parasite within the IRBC is modeled as a rigid object. This model is applied to the stretching of IRBCs by optical tweezers, the deformation of IRBCs in shear flow, and the occlusion of narrow channels by IRBCs. We also investigate the effects of IRBCs on the rheological property of blood in micro-channels. Our results indicate that apparent viscosity is drastically increased for the period from the ring stage and the trophozoite stage, whereas it is not altered in the early stage of infection. © 2010 Elsevier Ltd.
Source Title: Journal of Biomechanics
ISSN: 00219290
DOI: 10.1016/j.jbiomech.2010.01.011
Appears in Collections:Staff Publications

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