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Title: Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering
Authors: Ravichandran, R.
Seitz, V.
Reddy Venugopal, J. 
Sridhar, R.
Sundarrajan, S. 
Mukherjee, S.
Wintermantel, E.
Ramakrishna, S. 
Keywords: Cardiogenic differentiation
Ischemic myocardium
Mesenchymal stem cells
Phytic acid
Issue Date: Mar-2013
Citation: Ravichandran, R., Seitz, V., Reddy Venugopal, J., Sridhar, R., Sundarrajan, S., Mukherjee, S., Wintermantel, E., Ramakrishna, S. (2013-03). Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering. Macromolecular Bioscience 13 (3) : 366-375. ScholarBank@NUS Repository.
Abstract: A functional scaffold fabricated is developed from natural polymers, favoring regeneration of the ischemic myocardium. Hemoglobin/gelatin/fibrinogen (Hb/gel/fib) nanofibers are fabricated by electrospinning and are characterized for morphology, scaffold composition, functional groups and hydrophilicity. It is hypothesized that ex vivo pretreatment of mesenchymal stem cells (MSCs) using 5-azacytidine and such a functional nanofibrous construct having a high oxygen-carrying potential could lead to enhanced cardiomyogenic differentiation of MSCs and result in superior biological and functional effects. The combination of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Bioscience
ISSN: 16165187
DOI: 10.1002/mabi.201200391
Appears in Collections:Staff Publications

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