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Title: Lateral ridge augmentation using a PCL-TCP scaffold in a clinically relevant but challenging micropig model
Authors: Yeo, A.
Cheok, C.
Teoh, S.H. 
Zhang, Z.Y. 
Buser, D.
Bosshardt, D.D.
Keywords: Dentoalveolar
Guided bone regeneration
Issue Date: Dec-2012
Citation: Yeo, A., Cheok, C., Teoh, S.H., Zhang, Z.Y., Buser, D., Bosshardt, D.D. (2012-12). Lateral ridge augmentation using a PCL-TCP scaffold in a clinically relevant but challenging micropig model. Clinical Oral Implants Research 23 (12) : 1322-1332. ScholarBank@NUS Repository.
Abstract: Background: In implant dentistry, there is a need for synthetic bone substitute blocks to support ridge augmentation in situations where large bone volumes are missing. Polycaprolactone-based scaffolds demonstrated excellent results in bone tissue engineering applications. The use of customized polycaprolactone-tricalcium phosphate (PCL-TCP) displayed promising results from recent rat femur and rabbit calvaria studies. However, data from clinically representative models in larger animals do not exist. Objective: To evaluate new bone formation in association with a novel PCL-TCP scaffold in comparison with an autogenous bone block graft for the reconstruction of large dentoalveolar defects in a clinically relevant but challenging pig jaw model. Material and methods: Chronic, non-contained one-wall defects were created in the mandible of micropigs and randomly assigned to receive one of the following guided bone regeneration (GBR) procedures for a period of 6 months. (A) Collagen membrane + autogenous block graft or (B) Collagen membrane + PCL-TCP scaffold. Micro computed tomography (μ-CT), histology and histomorphometry were used to assess new bone formation. Results: Although μ-CT and histomorphometric analysis demonstrated a slight discrepancy between the measurements, the group utilizing autogenous bone grafts consistently reported superior new bone formation as compared to PCL-TCP scaffolds. When measured using μ-CT, the ratio of bone volume fraction for PCL-TCP scaffolds with respect to autografts yielded a mean efficacy of approximately 51%. Histological examination revealed that under favorable conditions, the new bone matrix and new bone marrow were in direct contact with the PCL-TCP scaffold rods and invading the interstices, suggesting good biocompatibility and high osteoconductivity. Autograft block grafts demonstrated 48.5-57.4% of pronounced resorption after 6 months following ridge augmentation. Conclusions: PCL-TCP scaffolds have demonstrated the potential application for lateral ridge augmentation following a healing period of 6 months in a micropig model. © 2011 John Wiley & Sons A/S.
Source Title: Clinical Oral Implants Research
ISSN: 09057161
DOI: 10.1111/j.1600-0501.2011.02366.x
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