Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cellbi.2005.03.026
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dc.titleIn vitro study of smooth muscle cells on polycaprolactone and collagen nanofibrous matrices
dc.contributor.authorVenugopal, J.
dc.contributor.authorMa, L.L.
dc.contributor.authorYong, T.
dc.contributor.authorRamakrishna, S.
dc.date.accessioned2014-06-17T06:24:06Z
dc.date.available2014-06-17T06:24:06Z
dc.date.issued2005-10
dc.identifier.citationVenugopal, J., Ma, L.L., Yong, T., Ramakrishna, S. (2005-10). In vitro study of smooth muscle cells on polycaprolactone and collagen nanofibrous matrices. Cell Biology International 29 (10) : 861-867. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cellbi.2005.03.026
dc.identifier.issn10656995
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/60513
dc.description.abstractBiodegradable polycaprolactone and collagen nanofibers were produced by electrospinning, with fiber diameters of around 300-700 nm and features similar to the extracellular matrix of natural tissue. Human coronary artery smooth muscle cells (SMCs) seeded on nanofibrous matrices tend to maintain normal phenotypic shape and growth tends to be guided by the nanofiber orientation. The SMC and nanofibrous matrix interaction was observed by SEM, MTS assay, trypan blue exclusion method and laser scanning confocal microscopy. The results showed that the proliferation and growth rate of SMCs were not different on polycaprolactone (PCL) nanofibrous matrices coated with collagen or tissue culture plates. PCL nanofibrous matrices coated with collagen showed that the SMCs migrated towards inside the nanofibrous matrices and formed smooth muscle tissue. This approach may be useful for engineering a variety of tissues in various structures and shapes, and also to demonstrate the importance of matching both the initial mechanical properties and degradation rate of nanofibrous matrices to the specific tissue engineering. © 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cellbi.2005.03.026
dc.sourceScopus
dc.subjectCollagen
dc.subjectNanofibers
dc.subjectPolycaprolactone
dc.subjectSmooth muscle cells
dc.subjectTissue engineering
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.cellbi.2005.03.026
dc.description.sourcetitleCell Biology International
dc.description.volume29
dc.description.issue10
dc.description.page861-867
dc.description.codenCBIIE
dc.identifier.isiut000232508000005
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