Please use this identifier to cite or link to this item: https://doi.org/10.1177/0883911509358811
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dc.titleIn vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite
dc.contributor.authorLiao, S.
dc.contributor.authorWei, W.
dc.contributor.authorYokoyama, A.
dc.contributor.authorYuhue, Z.
dc.contributor.authorWatari, F.
dc.contributor.authorRamakrishna, S.
dc.contributor.authorChan, C.K.
dc.date.accessioned2014-06-17T06:24:02Z
dc.date.available2014-06-17T06:24:02Z
dc.date.issued2010-03
dc.identifier.citationLiao, S., Wei, W., Yokoyama, A., Yuhue, Z., Watari, F., Ramakrishna, S., Chan, C.K. (2010-03). In vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite. Journal of Bioactive and Compatible Polymers 25 (2) : 154-168. ScholarBank@NUS Repository. https://doi.org/10.1177/0883911509358811
dc.identifier.issn08839115
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/60508
dc.description.abstractA three-layered nano-carbonated hydroxyapatite/collagen/poly (lactic-co-glycolic acid) (nCHAC/PLGA) composite membrane that consisted of 8 wt% nCHAC + PLGA/4 wt%nCHAC + PLGA/PLGA was developed using a layer-by-layer casting. The human periodontal ligament and osteoblastic MC3T3-E1 cells were cultured on the three-layered composite membrane; the co-culture gave a more positive response than the pure PLGA membrane. Subsequently, the composite and pure PLGA membranes were implanted into critical 6.2 mm defects in rat crania. After 4 weeks, significant healing was observed in the defects implanted with the nCHAC/PLGA composite membrane, while similar healing was only observed with pure PLGA implants after 8 weeks. This novel composite appears to be a very promising candidate for periodontal and bone defects therapy.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1177/0883911509358811
dc.sourceScopus
dc.subjectBiodegradable
dc.subjectCritical defects.
dc.subjectFunctional graded material
dc.subjectGuided tissue regeneration
dc.subjectHuman periodontal ligament
dc.subjectNano-carbonated hydroxyapatite
dc.subjectOsteoblastic MC3T3-E1 cells
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentORTHOPAEDIC SURGERY
dc.description.doi10.1177/0883911509358811
dc.description.sourcetitleJournal of Bioactive and Compatible Polymers
dc.description.volume25
dc.description.issue2
dc.description.page154-168
dc.description.codenJBCPE
dc.identifier.isiut000274532200003
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