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Title: In vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite
Authors: Liao, S. 
Wei, W.
Yokoyama, A.
Yuhue, Z.
Watari, F.
Ramakrishna, S. 
Chan, C.K. 
Keywords: Biodegradable
Critical defects.
Functional graded material
Guided tissue regeneration
Human periodontal ligament
Nano-carbonated hydroxyapatite
Osteoblastic MC3T3-E1 cells
Issue Date: Mar-2010
Citation: Liao, S., Wei, W., Yokoyama, A., Yuhue, Z., Watari, F., Ramakrishna, S., Chan, C.K. (2010-03). In vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite. Journal of Bioactive and Compatible Polymers 25 (2) : 154-168. ScholarBank@NUS Repository.
Abstract: A three-layered nano-carbonated hydroxyapatite/collagen/poly (lactic-co-glycolic acid) (nCHAC/PLGA) composite membrane that consisted of 8 wt% nCHAC + PLGA/4 wt%nCHAC + PLGA/PLGA was developed using a layer-by-layer casting. The human periodontal ligament and osteoblastic MC3T3-E1 cells were cultured on the three-layered composite membrane; the co-culture gave a more positive response than the pure PLGA membrane. Subsequently, the composite and pure PLGA membranes were implanted into critical 6.2 mm defects in rat crania. After 4 weeks, significant healing was observed in the defects implanted with the nCHAC/PLGA composite membrane, while similar healing was only observed with pure PLGA implants after 8 weeks. This novel composite appears to be a very promising candidate for periodontal and bone defects therapy.
Source Title: Journal of Bioactive and Compatible Polymers
ISSN: 08839115
DOI: 10.1177/0883911509358811
Appears in Collections:Staff Publications

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