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|Title:||In vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite||Authors:||Liao, S.
Functional graded material
Guided tissue regeneration
Human periodontal ligament
Osteoblastic MC3T3-E1 cells
|Issue Date:||Mar-2010||Citation:||Liao, S., Wei, W., Yokoyama, A., Yuhue, Z., Watari, F., Ramakrishna, S., Chan, C.K. (2010-03). In vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite. Journal of Bioactive and Compatible Polymers 25 (2) : 154-168. ScholarBank@NUS Repository. https://doi.org/10.1177/0883911509358811||Abstract:||A three-layered nano-carbonated hydroxyapatite/collagen/poly (lactic-co-glycolic acid) (nCHAC/PLGA) composite membrane that consisted of 8 wt% nCHAC + PLGA/4 wt%nCHAC + PLGA/PLGA was developed using a layer-by-layer casting. The human periodontal ligament and osteoblastic MC3T3-E1 cells were cultured on the three-layered composite membrane; the co-culture gave a more positive response than the pure PLGA membrane. Subsequently, the composite and pure PLGA membranes were implanted into critical 6.2 mm defects in rat crania. After 4 weeks, significant healing was observed in the defects implanted with the nCHAC/PLGA composite membrane, while similar healing was only observed with pure PLGA implants after 8 weeks. This novel composite appears to be a very promising candidate for periodontal and bone defects therapy.||Source Title:||Journal of Bioactive and Compatible Polymers||URI:||http://scholarbank.nus.edu.sg/handle/10635/60508||ISSN:||08839115||DOI:||10.1177/0883911509358811|
|Appears in Collections:||Staff Publications|
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